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Alendronate is a bisphosphonate that binds to bone hydroxyapatite and precisely inhibits the action of osteoclasts, the bone-resorbing cells.Alendronate was not genotoxic during the in vitro microbial mutagenesis assay with and with out metabolic activation, within an in vitro mammalian cell mutagenesis assay, within an in vitro alkaline elution as